Cd1a negative langerhans cell histiocytosis: A case report

Cd1a negative langerhans cell histiocytosis: A case report

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Langerhans cell histiocytosis (LCH) is a rare histiocytic tumour in Hi Vis Vests adult.We report a case of LCH involving skull bones in a 35year old lady who presented with fever, headache and diabetes insipidus since two years.Radiological examination revealed osteolytic lesions in the parietal and occipital bones along with a solid, enhancing lesion VITAMIN D-3 1000IU in the pituitary infundibulum.Osteolytic lesions showed ttypical histomorphology of LCH on light microscopy and on IHC it was positive for SI 00 but negative for CD1 a.LCH with CD1 a negativity is very rare and hence we are presenting this case.